Latest news at the ROI Laboratory
Villa Joep Research Grant for Radiotherapy & OncoImmunology (ROI) lab
Renske van den Bijgaart and Gosse Adema from the Radiotherapy & OncoImmunology (ROI) laboratorium (Department of Radiation Oncology) in collaboration with the Prinses Maxima Center (Peter Hoogerbrugge) received a grant from Villa Joep (410 kEuro) entitled “Bifunctional anti-GD2 antibodies co-targeting innate immune checkpoints to improve immunotherapy of Neuroblastoma”. In this grant the ROI research team will develop novel bifunctional mAb formats that target the GD2 tumor-associated antigen on Neuroblastoma (NBL) and locally activate the immune system.
Award for one of our students
On September 18th, one of our students, Effrosyni Tsouri, was awarded the MSc. Molecular Mechanisms of Disease “Best Poster Award”, following the presentation of her first scientific poster. On the poster, she discussed the results of her internship at the department of Radiotherapy and Oncoimmunology.
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Welcome at our Laboratory
The experimental and clinical research program by the Radiotherapy & OncoImmunology Laboratory is aimed at:Molecular Immunology program
Dendritic cells (DC) are the professional antigen presenting cells (APC) of our immune system. They are able to initiate immune responses against pathogens or tumors, but also have the capacity to prevent (auto)-immune responses harmful to the host. My research is centered around the molecular and functional analysis of DC in mouse and man. Applying different molecular approaches at the genomic and proteomic level a set of novel DC-antigens have been identified, including chemokines (DC-CK1, CXCL16), a novel multiple membrane spanning receptor (DC-STAMP), a transcription regulator (DC-SCRIPT). Knowledge regarding DC-immuno-biology is essential for the development and design of DC-based vaccines in mouse models as well as in clinical studies in cancer patients. More recently, regulatory T cells that are crucially involved in balancing the immune system are studied at the molecular and functional level as well as in immunotherapy of cancer.VAMP
An important objective is the development of predictive profiles based on Vascular Architecture and Microenvironmental Parameters (VAMP). The ultimate goal is to provide a mechanistic basis for the optimization of treatments that combine radiotherapy with novel biological modifiers and for the development of patient selection strategies.More information about the research program is in the section Research.