Radiotherapy & OncoImmunology

Department of Radiation Oncology





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Latest news at the ROI Laboratory



Early Career Investigator Award for Eva-Leonne Göttgens


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Eva-Leonne Göttgens, PhD student at the Radiotherapy and OncoImmunology laboratory (ROI), has received an Early Career Investigator Award during the annual meeting of the Association for Radiation Research 2018 in Belfast. She presented the results of her collaboration with the Oxford Institute for Radiation Oncology and the ROI laboratory, which included new radiosensitising treatment strategies for head and neck squamous cell carcinomas.


Jeroen Slaats received the AIO award


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At the Annual Dutch Tumor Immunology Meeting 2018, Jeroen Slaats, theme Cancer development and immune defense, received the AIO award for his presentation: “Tumor immune escape: Releasing the handcuffs from cytotoxic T cells”. The award includes a €500 travel grant.



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Welcome at our Laboratory

The experimental and clinical research program by the Radiotherapy & OncoImmunology Laboratory is aimed at:

Molecular Immunology program

Dendritic cells (DC) are the professional antigen presenting cells (APC) of our immune system. They are able to initiate immune responses against pathogens or tumors, but also have the capacity to prevent (auto)-immune responses harmful to the host. My research is centered around the molecular and functional analysis of DC in mouse and man. Applying different molecular approaches at the genomic and proteomic level a set of novel DC-antigens have been identified, including chemokines (DC-CK1, CXCL16), a novel multiple membrane spanning receptor (DC-STAMP), a transcription regulator (DC-SCRIPT). Knowledge regarding DC-immuno-biology is essential for the development and design of DC-based vaccines in mouse models as well as in clinical studies in cancer patients. More recently, regulatory T cells that are crucially involved in balancing the immune system are studied at the molecular and functional level as well as in immunotherapy of cancer.

VAMP

An important objective is the development of predictive profiles based on Vascular Architecture and Microenvironmental Parameters (VAMP). The ultimate goal is to provide a mechanistic basis for the optimization of treatments that combine radiotherapy with novel biological modifiers and for the development of patient selection strategies.

More information about the research program is in the section Research.